Optometrist reviewing myopia control clinical trial data at Eyecare Concepts Melbourne
Evidence-Based Care

The Evidence Behind Myopia Management

Every recommendation we make is grounded in published clinical trial evidence. This page explains what that evidence actually shows, and how we translate it into a plan for your child.

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Why We Lead With Evidence, Not Products

Myopia management has grown quickly, and with that growth has come a genuinely large number of products, devices and claims, not all of them equally well supported. Our approach starts from the published research, not the other way around: we look at what the trial evidence actually shows for a treatment, then decide where it fits in a child's care, rather than choosing a product first and looking for evidence to justify it after.

This matters because myopia control isn't cosmetic. It's treatment aimed at reducing lifetime risk of sight-threatening eye disease, covered in detail on our Myopia-Related Eye Diseases page. Every dioptre and every millimetre of axial length genuinely matters, so the treatments used to influence them deserve real scrutiny.

evidence-based-treatment-02.jpg — Clinical Trial Data Chart On Screen
evidence-based-treatment-03.jpg — Optical Biometer Measuring Axial Length

What Good Evidence Actually Measures

The strongest myopia control trials are randomised controlled trials that track axial length, not just prescription, over one to three years, comparing a treatment group against children wearing standard single-vision correction. Axial length is used because it's the more direct, objective marker of how much the eye is actually growing, less easily confounded than a prescription reading.

Results are usually reported as a percentage reduction in axial elongation compared with the control group. This gives us a genuinely useful basis for comparison between studies of the same treatment, though, as covered below, comparing percentages across different treatments and different trials needs care.

The Evidence Base

How We Group The Evidence

Rather than ranking treatments by exact percentages, which aren't reliably comparable across different trials, we group them into broad tiers based on the overall weight of published evidence, an approach also used by respected clinical education resources such as Myopia Profile.

1

Most Effective (~50% Or Greater Reduction)

OrthoK, MiSight contact lenses, MiyoSMART and Stellest spectacle lenses, 0.05% atropine, and repeated low-level red-light therapy (RLRL) each show around 50% or more reduction in axial elongation across multiple studies, with no single option shown to be clearly superior to the others in this tier. RLRL's evidence base has grown substantially: a 2022 multicentre randomised trial first established its efficacy, and a real-world cohort study of nearly 2,900 children followed for up to five years has since shown effective axial length control sustained across every year of follow-up, which is why we no longer consider it an early-stage option.

2

Moderately Effective (Around 33% Reduction)

Treatments such as 0.025% atropine and certain other soft multifocal contact lens designs show meaningful but somewhat smaller average effects in trials.

3

Minimally Effective

Very low-dose atropine (0.01%) and standard progressive addition spectacle lenses show only modest effects in most trials, and are generally not our first recommendation where a more effective option is suitable.

4

Emerging Evidence

Pre-myopia intervention, such as plano or low-plus peripheral defocus lenses and low-dose atropine for at-risk, not-yet-myopic children, remains a newer area with promising early trial results and a smaller but rapidly growing evidence base than the more established treatments above.

A Note On Comparing Percentages Across Studies

Percentage efficacy figures are not directly comparable between different trials, since study populations, ethnicities, follow-up periods and control groups all differ. A 60% result in one study doesn't necessarily mean greater real-world effectiveness than a 50% result in another. This is exactly why we use broad evidence tiers, and clinical judgement, rather than treating percentages as a precise ranking. See our Myopia Control Treatments page for how each option compares in more detail.

From Evidence To Individual Care

How Evidence Becomes Your Child's Plan

Strong trial evidence tells us how a treatment performs on average across a study population. Turning that into the right recommendation for one specific child takes clinical reasoning as well.

Which Treatments Suit This Child

We start from the most effective evidence tier where possible, then narrow based on age, prescription and eye health.

Glasses, Contact Lenses Or Overnight Wear

Lifestyle, sport, and a child's comfort with lens handling or overnight wear all narrow the realistic options further.

What Will Actually Be Worn Consistently

Compliance is one of the biggest real-world drivers of outcome. A slightly less “top-tier” treatment worn reliably often outperforms a higher-evidence option worn inconsistently.

Where The Evidence Is Heading

Myopia management remains one of the more active areas of eye health research. Bodies such as the International Myopia Institute (IMI) publish regularly updated white papers summarising the global evidence base and clinical management guidelines, which we follow closely alongside the published literature itself and clinician-focused summaries such as Myopia Profile.

Current areas of active research include combination therapy, pairing a lens-based treatment with atropine for children who need more than a single treatment offers; intervening even earlier, in at-risk children before myopia technically begins, covered on our Preventing Myopia page; and further optimising red-light therapy protocols for younger children and those who need extra support with adherence. We treat this as a living evidence base, and our recommendations evolve as it does, not as a fixed set of products we default to indefinitely. RLRL is a good example of that evolution in practice: it moved from a promising early-stage treatment to one backed by real-world, five-year outcome data in the space of only a few years, and we update our own recommendations as the evidence itself matures.

evidence-based-treatment-04.jpg — Journal Articles And Research Papers On Myopia
evidence-based-treatment-05.jpg — Myopia Management Consultation Photo
Common Questions

Evidence-Based Treatment: FAQs

Is myopia control actually backed by real evidence, or is it marketing?
It's genuinely backed by randomised controlled trials, the same standard of evidence used to approve most medical treatments. OrthoK, MiSight, MiyoSMART, Stellest and low-dose atropine have all been studied in trials specifically measuring their effect on axial elongation, not just the resulting prescription.
What does a 'clinical trial' for myopia control actually measure?
The best trials measure axial length, the physical growth of the eye, over one to three years, comparing children on the treatment against a control group using standard single-vision correction. Axial length is used because it's a more direct, objective measure of underlying eye growth than prescription alone, which can be affected by other factors.
Why do different studies report different effectiveness percentages?
Study populations, ethnicities, follow-up length, and control groups all differ between trials, so results aren't directly comparable on a like-for-like basis. This is why we group treatments into broad evidence tiers, most effective, moderately effective, and minimally effective, rather than ranking by exact percentages.
Who sets the standards for myopia management evidence?
Bodies such as the International Myopia Institute (IMI) publish regularly updated white papers summarising the global evidence base and clinical management guidelines, drawing on the full body of published trials rather than any single study or manufacturer's data.
Does more evidence mean a treatment is automatically the right choice for my child?
Not on its own. Strong evidence tells us a treatment works well on average across a trial population. Whether it's the right choice for an individual child also depends on their age, prescription, lifestyle and, importantly, whether they'll actually wear or use it consistently, since compliance is one of the biggest real-world drivers of outcome.
How do you stay current as the evidence changes?
Myopia management is one of the more active areas of eye health research, with new trial data published regularly. We follow the published literature and updated clinical guidelines, including IMI white papers and sources like Myopia Profile, which summarise emerging evidence for treating clinicians, so our recommendations reflect current evidence rather than becoming outdated.
What is a randomised controlled trial, and why does it matter here?
It's a study design where children are randomly assigned to a treatment or comparison group, which controls for other factors that might otherwise explain the results. It's considered the strongest form of evidence for whether a treatment genuinely causes an effect, rather than simply being associated with one.
Do you rely on studies funded by lens or drug manufacturers?
Some key trials are manufacturer-sponsored, which is common in eye health research generally, but we weigh findings against independent studies, meta-analyses and real-world data wherever available, rather than relying on any single sponsored trial alone.
Does a bigger study automatically mean more reliable evidence?
Generally, larger, well-designed studies with longer follow-up give more reliable, generalisable results than small or short studies, though study quality and design matter as much as raw size. We weigh both when assessing an evidence base.
Where can I read the research myself?
Many of the studies and white papers we draw on are published in open-access journals or summarised by resources such as the International Myopia Institute and Myopia Profile. We're happy to point interested parents toward specific sources at a consultation.

Evidence-Based Care, Built Around Your Child

Book a comprehensive myopia assessment and we'll explain exactly what the evidence supports for your child's specific situation, not a one-size-fits-all recommendation.

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